Taxotere And Its Relation To Permanent Hair Loss

Oct 19, 2016 by

Drug manufacturer Sanofi Aventis has recently been barraged by lawsuits in relation to its drug taxotere. Studies have shown a relation between taxotere and alopecia induced by chemotherapy drug. Hair loss is one of the usual side effects of chemotherapy but patients expect their hair to grow back in a period of 3 to 6 months. But instead of growth, patients reportedly suffered from permanent and irreversible hair loss.

Taxotere is designed to treat certain cancers such as breast cancers, prostate cancer, and advanced stomach cancer. The drug helps prevent cancer cells from developing in the patient’s body. Some patients alleged that the opposite happened causing them to lose their hair. In a study published in the Annals of Oncology, it was revealed that docetaxel is associated with an increased risk of permanent alopecia. The study involved 20 female patients who were treated for breast cancer, treated taxotere, and developed permanent alopecia.

Several studies have been conducted in order to determine the relation between taxotere and permanent hair loss. The GEICAM 9805, funded by Sanofi, came up with the conclusion that 9.2 percent of patients experienced hair loss that lasted for more than 10 years based from data presented in the Ami Dodson lawsuit. A study conducted by Dr. Scot Sedlacek, on the other hand, revealed that taxotere could cause 6 percent of women to suffer permanent alopecia.

In recent studies, Taxotere showed better performance in extending the survival of breast cancer patients. But studies have also revealed a distressing side effect for patients and that is permanent hair loss. For this reason, the manufacturer of the drug Sanofi faces a growing number of lawsuits filed by women for their failure to warn them about the severity and permanence of hair loss. According to them, if they were informed about the potential of hair loss, they would have opted for another treatment.

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Reduced Settlement for Actos Bellwether Trial

Feb 24, 2015 by

The first lawsuit against Takeda Pharmaceuticals USA Inc. and Eli Lilly and Co. for their participation in the manufacture and marketing of the diabetic medication Actos has ended in settlement. The initial amount was for $9 billion but it was eventually reduced to $37 million by Western District of Louisiana judge Rebecca Doherty.

The lawsuit was the first to go to trial with the claim that Actos is associated with increasing a diabetic patient’s risk of bladder cancer. A motion by Takeda and Eli Lilly for a new trial was denied by the judge, and maintained that the $27.6 million against the Takeda and $9.2 million against Eli Lilly was not unreasonable considering the evidence.

Actos (pioglitazone hydrochloride) is one of the thiazolidinediones class of drugs used to manage type 2 diabetes. It had been mainly marketed as the safer alternative because it appeared to avoid the risk of congestive heart failure (CHF) a common side effect of glitazones because they caused the body to retain water. However, it turns out that it does increase the risk of CHF as well as liver disease, fractures, and bladder cancer from prolonged use. An personal injury lawyer will be able to tell you that the fact the manufacturers knew Actos carried these risks but failed to warn physicians and patients about them is a strong basis for the lawsuits against Takeda and Eli Lilly. Moreover, a whistleblower lawsuit revealed that the companies had known about the link about myocardial infarction and Actos since 2005 but it was only in 2011 that independent studies revealed these risks. The product has been pulled out of the German and French markets but continues to be prescribed in the US with additional warning of these risks.

If you have been seriously injured or harmed from using Actos, you may be able to get compensation. Contact an personal injury lawyer in your area for more information.

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When Medicine Becomes More Dangerous than Safe

Apr 9, 2014 by

Whenever bodily pains and other minor ailments attack, many take medicine to get relief. This is the same where severe illnesses are the causes of health problems, but instead of over-the-counter medications, people, instead, take prescribed drugs, due to the seriousness of the health condition and the higher chemical contents of the drug to be used.

The use of drugs has long been part of medical treatment. And many kinds of drugs have been major factors in treating different kinds of diseases, both minor and severe. Due to differences, however, in overall health condition, immune system, family history or other medication taken, some drugs fail to provide the desired and intended beneficial results, so that what works effectively to some causes adverse effects in others.

Before the US Food and Drug Administration approves a newly formulated drug for prescription and market use, the pharmaceutical company that manufactured it should first be able to prove its safe and effective use through clinical tests. But since the funds needed in conducting tests on a particular drug come from the drug’s manufacturer, such manufacturer, sometimes, is able to control the release of test results, forwarding to the FDA only the drug’s positive effects: thus, the danger of some drugs to a number of users.

Regardless of how tests were conducted and what results were actually attained, the following drugs have been linked to severe adverse effects and the death of a number of patients of who have taken them: Yasmin, Testosterone supplements and Reglan.

Yasmin is a pregnancy-prevention oral contraceptive that was introduced by the German firm Bayer Healthcare Pharmaceuticals in 2001. It was also found to be an effective remedy for temperate acne and Premenstrual Dysphoric Disorder (PMDD). Users of Yasmin were later said to be exposed to high risks of heart attack, stroke and death, as well as in developing gallbladder injuries, blood clots, such as deep vein thrombosis or pulmonary embolism. The drug was also linked to the death of 23 Canadian women, aged between 14 and 44, who have been using it for months.

The number of Yasmin lawsuits has already reached thousands– from women who have developed blood clots while taking it. Being one of the most sold oral contraceptives in the US and around the world, many more lawsuits are expected to be filed.

In the case of Testosterone supplements, the identified Low T drug side effects include stroke, heart attack, and death. Testosterone supplement was intended to enhance the production of testosterone, the hormone responsible for sexual function, sex drive, distribution and growth of male hair, and the development of the prostate and different male sex organs. Thus, for males suffering from Hypogonadism or low testosterone (low T), the drug supplement was supposed to be an effective solution. According to the site of Williams Kherkher, a study that was posted from a Lancet article concluded that younger men that were taking the testosterone supplement had more risks posed by the medication than benefits.

Then there is Reglan, the FDA approved oral drug intended to treat nausea caused by chemotherapy, post-surgery nausea, gastrointestinal disorder and diabetic gastroparesis, a failure of the stomach to contract and empty.

In February 2009 the FDA issued a black box warning, explaining the risks of taking Reglan, due to its proven connection to the development of Tardive Dyskinesia, a neurological syndrome. The illness involves uncontrolled, repetitive and rapid movements of the trunk, arms, fingers and legs, tongue protrusion, rapid eye blinking, and pursing and puckering lips. Other side-effects of Reglan included seizures or convulsions, symptoms of Parkinson’s disease and Neuroleptic Malignant Syndrome (NMS), a serious condition that can cause high fever, muscular rigidity, unconsciousness, unstable blood pressure and death. Despite the danger of its use, immediately stopping the use of the drug may also prove to be equally dangerous, as this too may induce the development of other side effects.

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